A correlation study of arterial stiffness, cardiac autonomic neuropathy and lipid profile in type 2 diabetes mellitus patients

Objectives: Micro and macrovasculopathy are common complications of undertreated or undiagnosed type 2 diabetes mellitus (T2DM) patients. One the underlying factors is arterial stiffness, which may lead to cardiovascular cerebrovascular diseases. Understandably, diabetic micro affect vital functions, well-being individual. However, few studies have attempted determine cardiac autonomic neuropathy (CAN) lipid profile separately in South Asian population examined its associations with T2DM. Moreover, there a need understand mechanistic links among risk factors. This forms basis present study. Materials Methods: T2DM patients 53–62 years age- gender-matched healthy control subjects were recruited cross-sectional observational study ( n = 30 each, eight women). Anthropometric measurements, physiological parameters such as resting heart rate, peripheral blood pressure (PBP), central (CBP), augmentation index% (AIx%), brachial-ankle pulse wave velocity II ECG for analysis rate variability recorded after obtaining consent participants. The fasting glucose also analysed. Results: Peripheral systolic was significantly higher P 0.05) Dyslipidaemia evident Atherogenic index plasma (AIP) Correlation revealed positive association between AIx% PBP CBP well AIP pressure, serum triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) very (VLDL-C) levels. found be negatively associated HF (nu). Serum TG, high-density (HDL-C) levels emerged significant independent predictors vasculopathy by multiple regression analysis. Conclusion: In study, atherogenic dyslipidaemia observed combination increased VLDL-C decreased HDL-C. index, predictor risk, dysregulation nervous system those A noninvasive, surrogate markers stiffness indicates that enhanced elevate systemic pressure. Therefore, early screening estimation profile, performed unravel vasculopathy.